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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

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This was in comparison to the control group where both males and females showed increased body adiposity while body adiposity and weight of gonadal fat pads decreased in KIR and KID mice [3]